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Dear Mark, I have written to you before about Rytary which I have given up on. I was dxed in 2004, age 52. I was started on Sinemet I think very soon after. I checked & as far back as I can find (2009) I have been taking Ropinirole ER 4mg, Amantidine 100 mg, Azilect 1 mg once daily plus 10 mg c/l 6 x daily. I am having little on times & a lot of freezing & off times. I asked my neuro about changing meds & he said I'm on the best ones but I was wondering if my body is immune to them & a change might help. Any thoughts would be greatly appreciated. Thank you, Brenda