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  1. After carefully researching; thinking about; and talking about medical marijuana for several months, I finally decided to try medical marijuana for my tremor, which is the one symptom that I haven't been able to improve with exercise. In fact, despite my exercise, my tremor has gotten worse in the past few months and is now almost a constant issue. I live in a state where marijuana is illegal, but decriminalized. I know that sounds like doubletalk, and it is. Possession of less than 100 grams of marijuana (about 3 1/2 ounces) is a minor misdemeanor, which is punishable by a fine of $150 but does not give you a criminal record. It's ridiculous, but that is the law in my state. My first obstacle was finding some marijuana that would be safe and effective. With no medical marijuana in my state and therefore no dispensaries, I would be buying my marijuana "off the street", so to speak. I don't know a single person that does drugs, so I didn't know how to proceed. As it turned out, my wife had heard that the wife of a business associate smoked marijuana. I met with her business associate to explain the situation and ask for his help. He knew who to contact. He told the grower about my PD and asked the grower which strain he thought would be helpful. I was expecting him to sell me 1/4 ounce (about 7 grams) for $80, but when I met with him last night, the grower had given me a small sample (about 3 grams) to try for free. The marijuana strain is "Lemon Kush", which is an indica dominant strain that is reportedly good for daytime use. The next issue was getting a vaporizer, as I planned to vaporize the marijuana instead of smoking it. I certainly don't need lung cancer in addition to PD. I went to a specialty store today. A young female clerk asked if she could help and I told her that I was looking for a vaporizer. She asked if I meant an e-cig and I said no. She asked what I intended to do with the vaporizer and I told her that I intended to use it for marijuana. Apparently, that is the wrong thing to say and she promptly shushed me. She informed me that the proper thing to say is that I was using it for "dry herbs". Apparently, there is a required lingo to be learned. After my marijuana etiquette lesson, I bought a Randy's Troo (pronounced 'true') portable vaporizer to use while I am waiting for my Haze V3 vaporizer to arrive in the mail next week. The Troo was relatively cheap at $69, but got a good review from the manager at the specialty shop. I took the Troo home; read the instructions; charged the Troo battery; and waited for my wife to get home from work. I wanted my wife to be home for my first use of marijuana. For one thing, I have no sense of smell, so I wanted her to determine if vaporizing the marijuana produced a strong scent; whether any smell would linger; and whether I smelled like marijuana after vaporizing it. As it turned out, according to my wife, vaporizing produced a mild marijuana scent that did not linger and I did not smell like marijuana afterwards. About 7pm, we were finished with dinner and ready to give the marijuana a try. I took a pinch (about the size of a pencil eraser) out of the container; crushed it between my thumb and forefinger; and put it on a small postage scale to weigh it. The least the scale will weigh is one gram, and my eraser sized dose was obviously below that. The scale read zero. I placed the marijuana in the bowl of the vaporizer and turned it on, setting the temperature at 280 degrees F. With the marijuana at the proper temperature, I began inhaling. I read that you should take long, slow draws and for the next 10 minutes that's exactly what I did. On the YouTube videos I watched, there would be a cloud when exhaling. I saw no cloud when I exhaled, but I did feel the heat in my throat. When 10 minutes were up, I felt absolutely no different, except that my heart rate had increased from 70 to 95. Did I do something wrong? Did I use too little marijuana? Was the temperature wrong? Was I immune to the effects of marijuana? I emptied the used marijuana out of my vaporizer and it was still the same green color as when I put it in. The videos I saw on the internet said that after vaporizing, the marijuana should look brown, but not black. I decided that I messed up and decided to try again. This time, I ground the (used) marijuana up with a spoon and put it back in the vaporizer. I turned the vaporizer back on and started attempt #2. This time, I saw a small cloud when I exhaled. Toward the end of the 10 minutes, I started to feel a buzz. When I closed my eyes, I felt a slight spinning sensation. My pulse was still at 95 and I felt wide awake. I got up and walked around. I ate my after dinner dessert. A few minutes after finishing the marijuana, I notice that my tremor had stopped, which I did not expect. About 9pm, I fell asleep and slept very deeply until midnight. I am now wide awake - at 2 am. I had no more than a few seconds of tremor after vaporizing the marijuana until I woke up at midnight. When I woke up, I felt somewhat hung over, but fortunately that only lasted about a half hour. At this point (2 am), my tremor is back. The lesson learned is that the marijuana needs to be ground up well if you intend to vaporize it (at least with my Troo). I also learned that a tiny bit of marijuana is very potent, at least for a newbie. Obviously, I don't know whether the 5 hour relief from my tremor was due to the marijuana or if it was simply a coincidence. Time will tell. I wonder if the tremor stopped because I was buzzed? If so, that is of very limited value. I've got to be clear-headed and able to function normally, so being buzzed is not really an option. I also discovered that I could not drive or be out in public with this evening's level of buzz. The break in the tremor was very nice, but I can't be stoned. Perhaps using less marijuana would be better. Perhaps I just need to acclimate to the marijuana. I'm anxious to determine whether the marijuana will affect my tremor and whether I can find a lower dose of marijuana that will stop the tremor and not give me a buzz. I also need to find a precise method of measuring the proper amount of marijuana to vaporize. My intention is to use medical marijuana every evening (once per day) for the next 90 days to evaluate its effect on my tremor. My hope would be to find a very low dose of marijuana that could be used to stop my tremor all day long.
  2. Un estudio reciente de 116 participantes con historia de uso de drogas, comparó los cambios por Ultrasonido Transcraneal y en el examen físico motor de aquellos con uso de anfetaminas con aquellos con uso de otras drogas (ecstasy, marijuana) o sin consumo previo de drogas. Los resultados mostraron que aquellos en anfetaminas, tenían en el Ultrasonido un área de ecogenicidad mayor (similar a lo que se ve en Parkinson) en comparación con los otros grupos. También dicho grupo mostró puntajes más altos en el UPDRS (Escala motora del Parkinson). Los autores concluyen que sus resultados apoyan la teoría que las anfetaminas aumentan el riesgo de Parkinson. OJO! Los resultados deben de interpretarse cautelosamente, por las siguientes razones: 1. La muestra o número de participantes fue pequeño 2. No sabemos si los cambios persisten con el tiempo 3. Algunos pacientes tenían depresión, lo que puede afectar los resultados 4. Los participantes fueron reclutados por medio de anuncios en la comunidad, lo que limita la selección de participantes Definitivamente se requieren de estudio mas grandes y con un seguimiento adecuado para confirmar estos resultados. http://www.ncbi.nlm.nih.gov/pubmed/26923520 Saludos, DMR @drdanielmtz
  3. The Breakthrough Therapies for Parkinson’s Disease Every Patient and Caregiver Should Know About Paperback and Kindle Versions Available at Amazon.com http://www.amazon.com/10-Breakthrough-Therapies-Parkinsons-Disease/dp/0692497412/ref=sr_1_40?ie=UTF8&qid=1441071806&sr=8-40&keywords=parkinson%27s+disease Ifeanyi Enoch Onuoha said, “every challenge you encounter in life is a fork in the road. You have the choice to choose which way to go: backward, forward, breakdown or breakthrough.” Since the publication of Parkinson’s Treatment 10 Secrets to a Happier Life with Parkinson’s Disease, the most common question we have received from patients is what are and what will be the next breakthrough therapies for Parkinson’s disease. A breakthrough is defined as a sudden increase in knowledge, improvement in technique, or fundamental advancement in understanding. Often breakthroughs occur when a formidable obstacle is penetrated. Breakthroughs are heralded as major achievements and they pave the road to meaningful progress in any disease. I have spent my entire professional career focused on Parkinson’s and related diseases. I have been blessed to spend much of my time taking care of patients, and I have evolved to understand the critical need for all those suffering to have access to information on breakthrough therapies. The point that I emphasize with my patients is that breakthrough ideas and therapies in Parkinson’s disease stretch far beyond a single drug or stem cell. There is, in fact, a broader and more exciting picture and portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior. Patients and families with personal investments in Parkinson’s disease should be informed and updated about all of the potential breakthrough therapies. So, “what will be the next breakthrough therapy?” Because of the complexity of the disease, each person possesses a different combination of bothersome symptoms. This complexity means that the answer to the next breakthrough therapy will vary patient to patient, and it could be a breakthrough in care as well as possibly a new device or drug. We have at the National Parkinson Foundation been monitoring the breakthroughs in the field. We run the free international Ask the Doctor web-based forum, and the questions posted have helped us to keep an accurate pulse on the field. Additionally, our blog called “What’s Hot in Parkinson’s Disease” as well as guest columns as the associate editor for the New England Journal of Medicine’s Journal Watch have provided the material, insight and inspiration for a new book; 10 Breakthrough Therapies in Parkinson’s Disease. Collectively, these experiences have provided focus for the topics in this book and in some cases the actual physical material. Several chapters include topics I have covered before, and in these cases I have added and updated information. The current book is an effort to provide a comprehensive review of the most important breakthrough therapies for Parkinson’s disease. Interestingly, these topics overlap with the most asked questions by patients and caregivers. The unexpected runaway success of my first book, “Parkinson’s Treatment: 10 Secrets to a Happier Life,” has provided hundreds of messages and an ocean of feedback from patients, families and researchers. The majority of comments I received on the first book were focused on the need to understand breakthrough therapies and approaches. My desire is that this book will fill a knowledge gap and will provide hope and valuable knowledge to those in the Parkinson’s disease community. Here are some of the topics that will be covered in the 10 Breakthrough Therapies for Parkinson’s Disease book released September 1, 2015: · Disease Modifying Drugs and Biomarkers · Coffee, Tea, Exercise, Interdisciplinary Teams and Caregivers · Extended Release/Novel Delivery Systems for Parkinson’s Disease Drug and When to Start Drug Therapy · Marijuana and Synthetic Cannabinoids · New Drugs for Hallucinations, Sleep, Constipation and Dizziness · Therapies While Hospitalized and Avoiding Hospitalization · Advancing Deep Brain Stimulation Technology, Earlier Intervention and Dopamine Pumps · Stem Cells and Stem Cell Tourism · Prions, Spreading Proteins, Vaccines and Growth Factors · The Drug Development Pipeline