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Hello All, I'm 43 and was diagnosed at 40. I'm married and have two school aged children and have been unable to work since Jan of last year due to cognitive issues. Last fall I tried going to a local center for PD patients but almost everyone there was in there 70's and 80's. There were a few younger people but they were in their 60's and had children my age or close to. Everyone was really nice but I couldn't relate to them. As the title states, I feel like I am loosing my mind. I used to have a really great memory (better than most) and was articulate (or so I was told). I could joke and make conversation with people fairly easily. I had an intellectually challenging job and worked my way up to a really good position within a large company. All that is gone now though. Now I feel like I am on an island. I've been able to maintain some of my pre-parkinson's friendships but the cognitive issues are really affecting me socially. I loose my words and train of thought during conversation. I recently have been unable to follow when people give me too complicated of instructions or speak too fast. I am having to limit the things I do for the family, ie. complicated paperwork... this was the first year I couldn't do our taxes. I got lost driving to my movement disorder specialist's office a couple of weeks ago. When I told her about it she said it was probably due to my Parkinson's meds wearing off. She sent me twice for neuropsyc testing over the past year and they say I have issues with executive functioning and slow processing but my memory is good (meaning it gets in and I can recall after a delay). I feel like a complete moron now a days. I am always behind in conversations and don't get a lot that would come to me easily. I freeze at times when I speak. Sometimes words pop into my head but I do not use them because I cannot remember what they mean until after the conversation is done. Likewise I am always remembering things... concepts and so on, after conversations are done. To top things off my wife still wants to socialize with other couples. Overall she's been very understanding, patient, and always there to help with with anything I need but she is a social person. As is my youngest child so I seem to always be around people feeling awkward and uncomfortable. Anyone else experiencing issues like this?
Dear Dr. Okun, Thank you much in advance for considering the question below 1) what are the cognitive impacts of Parkinson’s disease that may be more curable given the breakthroughs in treatment? 2) specifically, what is the underlying mechanism in how these treatments restore functions? 3) for example, if memory loss is treatable is this what is meant by ‘plasticity’? 4) does this potential cure completely repair the brain or neurons, synapses and pathways? 5) that is, does the proposed techniques restore actual memories, or does it only (only!) restore the ability to make and retrieve new memories from the time of treatment on? Another way to put the question is, with regard to recreated brain cells, is the patient like an open book, ready to form pathways anew? Or did the effect of Parkinson’s on the brain stop short of destroying interconnections?
revillapatient posted a topic in Ask The DoctorI'm writing this for my mom. She was diagnosed in Jan 2011 w/ PD: Symptoms were odd feeling in stomach from motions like stirring or washing hair. Also had a PD like gait, tremor in left hand, pain in left arm & high bp. I was started on 25/100 Sinemet 2x daily and stayed that way for 12 months. In Feb 2012 I was being treated for uncontrolled blood pressure & hospitalized for 7 days while they tried to get it under control. During that time, my PD diagnosis was questioned by hospital staff, I was taken off of Sinemet. After stopping Sinemet (I'm thinking now there's a connection to symptom) I had confusion. My blood pressure was never stabilized & I have since learned that I have an atrophic right kidney due to renal artery stenosis too severe to stent. My doctor is now talking about a nephrectomy due to multiple bp med combinations not making any difference (my morning bp runs about 200/100 as few bp meds in my system). I was exhausted, sleeping solidly 18 hours or so a day when I could, could barely shuffle and so in March 2012 I restarted Sinemet same dosage. I don't know that we noticed much difference after restarting and in July I was still weak, hard time walking, and started having some memory problems but mostly logic issues or concentration. I changed Neurologists & he said I had PD due to some physical tests & increased my dose of Sinemet. 1st I went to 1 25/100 3x per day for 2 weeks then 1.5 3x/day for the last 10 days w/ plans to increase to 2 3x/day in 4 days. I've now had worse memory issues & actually forgot my daughter briefly (2 minutes). I also tell stories that sound more like recounting a dream where all the facts don't go together & parts are left out. I know I'm having trouble while telling the story, but I don't realize how odd it is or unconnected. Others are telling me about the memory issues but I know I'm having trouble. My daughter noticed a few days ago it seemed to ramp up after my 2nd dosing of Sinemet & by evening I was almost acting tipsy-drunk. She reduced the evening Sinemet to 1 from 1.5 & we are thinking of doing the same to the afternoon dose. Complicating the connection is that I started a new bp med (Spironolactone) @ the same time as the Sinemet ramp-up. I've stopped it yesterday w/ dr's approval in case that was the cause. With the increased Sinemet, I do have more energy, but almost to the hyper side. And I eat everything in sight. I had blood work & head CT which all came back w/ no explanation for forgetting or dreamlike stories. I've told my neurologist everything but didn't get a call back Friday & that's why we reduced the Sinemet on our own as the memory thing is really scary. Long background story for a few questions: Can Sinemet cause these sudden odd stories & memory issues? Blood work showed dopamine level of 4412 when I was on 3 25/100 Sinemets a day. Is that normal? Can you have a sudden PD downslide to have ok memory one day & forget the daughter you've lived w/ for 9 months next. All memory & confusion episodes are brief (a few minutes to maybe 15 minutes). Any other suggestions/help would be so welcome. And of course, I'm in constant contact w/ my nephrologist & am only looking for other help. Thanks.