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Dr Okun I wrote you months ago asking which of the two, Prolopa or Sinemet is best for early stage.(see below your answer) I was diagnosed October 2014 and have done extremely well on just Azilect, however I believe it’s time to add one of the above. Im very healthy, active and still holding still with right side tremor with some rigidity. What side affects are you speaking of in your reply and with my above info do you think starting on 50/12.5 Prolopa is a wise start for me? Many thanks Discovery Prolopa and Sinemet are essentially both dopamine and different varieties are available in different countries. In early PD you can use these alone, or an agonist alone or a combination. They are both safe with MAO-B drugs like selegiline and rasagiline. I choose based on a detailed history, exam, and potential side effects.