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Dr. Okun

Post of the Week: High Hip Fracture Rate in Parkinson's Disease

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Dear forum members,


One huge issue in Parkinson's disease is the increased rate of hip fractures. Hip fractures can lead to increased morbidity and mortality so we want to do everything we can to prevent them. This study revealed a very high hip fracture rate among PD patients followed for 8 years. See your doc regularly, get regular bone scans (to be sure your bones are strong) and have regular evaluations by physical and occupational therapy-- these are strategies that when employed can lead to decreased fractures in the setting of PD. You have to try to prevent falls!! Good luck. The abstract from this recent article is pasted below:


Parkinsonism Relat Disord. 2012 Jan 30. [Epub ahead of print]

Parkinson's disease and risk of hip fracture: An 8-year follow-up study in Taiwan.

Chen YY, Cheng PY, Wu SL, Lai CH.


Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan; The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.



Patients with Parkinson's disease (PD) are subject to posture instability and falling. However, PD was not included as one of the risk factors in commonly used fracture risk calculation tools and the fracture rate in patients with PD was rarely reported. The aim of this study was to evaluate the risk of hip fracture in patients with PD.


Data were collected from the National Health Insurance Research Database of Taiwan. The study group included 394 patients with PD diagnosed in 1999-2000. The comparison cohort was comprised of 3940 age- and sex-matched patients from the same enrollment period. All patients were tracked from their index visits for eight years.


Hip fracture developed in 10.4% of patients with PD and 4.1% of patients in the comparison cohort during the follow-up period. Log-rank test analysis showed a significantly higher rate of hip fracture in PD. The Cox proportional regression model showed an adjusted hazard ratio of 2.71 (95% confidence interval = 1.92-3.83, P < 0.001) for patients with PD.


The hip fracture rate was as high as 10.4% in PD patients during 8 years follow-up period. While assessing the risk of hip fracture, PD should be taken into consideration. For those very high risk patients (elderly women with PD, osteoporosis, diabetes and diabetic neuropathy), many efforts should be made to prevent fracture.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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