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Dr. Okun

Post of the Week: Can Diabetes Increase Parkinson's Disease Risk

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Dear forum members,


The question as to diabetes increasing Parkinson's disease risk comes up with some regularity. This is an interesting Chinese study suggesting an increased risk, although we cannot take the data as conclusive. Here is the abstract from the recent study:


Diabetes Care. 2012 Mar 19. [Epub ahead of print]

Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications.

Sun Y, Chang YH, Chen HF, Su YH, Su HF, Li CY.


Department of Neurology, En Chu Kong Hospital, Sanxia District, New Taipei City, Taiwan.


OBJECTIVEWe retrospectively assessed the age- and sex-specific incidence and relative risk of Parkinson disease (PD) in Taiwan's diabetic population.RESEARCH DESIGN AND METHODSStudy cohort included 603,416 diabetic patients and 472,188 nondiabetic control subjects. Incidence rate and relative risk of PD (ICD-9-CM 332.0) were evaluated.RESULTSThe incidence of PD was 3.59 and 2.15 per 10,000 person-years for the diabetic and control group, respectively, representing a covariate adjusted hazard ratio (HR) of 1.61 (95% CI 1.56-1.66), which was substantially reduced to 1.37 (1.32-1.41) after adjusting for medical visits. Diabetes was associated with a significantly elevated risk of PD in all sex and age stratifications except in young women, with the highest HR noted for young men aged 21-40 years (2.10 [1.01-4.42]), followed by women aged 41-60 (2.05 [1.82-2.30]) and >60 years (1.65 [1.58-1.73]).CONCLUSIONSDiabetes is associated with an increased risk of PD onset in a Chinese population, and the relation is stronger in women and younger patients.

PMID: 22432112 [PubMed - as supplied by publisher]

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