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High doses of Thiamine HCL

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If you go to the Parkinson's forum on the website HealthUnlocked and put thiamine in the search window, you'll find many comments from PWP who are reporting high doses of thiamine are benefiting them greatly.  Dr. Constantine, in Italy, is following 2,500 patients on Thiamine HCL and reporting good results on nearly all of them. Is your organization aware of this?  If not, you may want to check it out because it's the most encouraging information available.  While it's all anecdotal, although the doctor has some studies, it's too many and too consistent to be ignored.

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I checked out the website.  I think the discussions about it stopping cell death of dopamine cells and delaying disease progression are premature.  There are indeed a lot of patients trying this approach and I found one open label study below which has serious methodological concerns.  We will keep an eye out for more studies and hopefully controlled studies and as more information becomes available we would be happy to share it.


J Altern Complement Med. 2015 Dec;21(12):740-7. doi: 10.1089/acm.2014.0353. Epub 2015 Oct 27.

Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study.



To investigate the potential clinical, restorative, and neuroprotective effects of long-term treatment with thiamine in Parkinson disease (PD).


Observational open-label pilot study.


Outpatient neurologic rehabilitation clinic.


Starting in June 2012, we have recruited 50 patients with PD (33 men and 17 women; mean age, 70.4 ± 12.9 years; mean disease duration, 7.3 ± 6.7 years). All the patients were assessed at baseline with the Unified Parkinson's Disease Rating Scale (UPDRS) and the Fatigue Severity Scale (FSS) and began treatment with 100 mg of thiamine administered intramuscularly twice a week, without any change to personal therapy. All the patients were re-evaluated after 1 month and then every 3 months during treatment.


Thiamine treatment led to significant improvement of motor and nonmotor symptoms: mean UPDRS scores (parts I-IV) improved from 38.55 ± 15.24 to 18.16 ± 15.08 (p = 2.4 × 10(-14), t test for paired data) within 3 months and remained stable over time; motor UPDRS part III score improved from 22.01 ± 8.57 to 9.92 ± 8.66 (p = 3.1 × 10(-22)). Some patients with a milder phenotype had complete clinical recovery. FSS scores, in six patients who had fatigue, improved from 53.00 ± 8.17 to 23.60 ± 7.77 (p < 0.0001, t test for paired data). Follow-up duration ranged from 95 to 831 days (mean, 291.6 ± 207.2 days).


Administration of parenteral high-dose thiamine was effective in reversing PD motor and nonmotor symptoms. The clinical improvement was stable over time in all the patients. From our clinical evidence, we hypothesize that a dysfunction of thiamine-dependent metabolic processes could cause selective neural damage in the centers typically affected by this disease and might be a fundamental molecular event provoking neurodegeneration. Thiamine could have both restorative and neuroprotective action in PD.

[Indexed for MEDLINE]

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