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Dr. Okun

New Study: New Brain Scans for Parkinson's- MEG

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Dear forum members,


There is some new technology that is finding its way to the PD-world. There are special scanners called MEG scanners that can look at the brain using magnetic fields and also can measure abnormal signals called oscillations. We hope these techniques will help speed research. See the abstract from the recent article below:


J Neurol Sci. 2009 Sep 1. [Epub ahead of print]

Use of magnetoencephalography (MEG) to study functional brain networks in neurodegenerative disorders.


Stam CJ.

Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands.

The pathophysiological mechanisms underlying clinical symptoms in neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) are incompletely understood. Magnetoencephalography (MEG) is a relatively new functional neuroimaging technique, which allows the simultaneous recording of the brain's magnetic activity from large arrays of sensors covering the whole head. MEG studies in PD and AD have identified characteristic patterns of abnormal oscillatory activity in different frequency bands. Furthermore, MEG studies aimed at the characterization of distributed functional networks have demonstrated distinct patterns of abnormal connectivity in demented and non-demented PD, as well as in AD. In PD abnormal oscillatory activity and disturbed connectivity may respond differently to dopaminergic treatment. Further studies in this field could benefit from new technological developments such as ultra low field MRI and from the application of a well-defined theoretical framework such as graph theory to the study of disturbed brain networks.

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