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Dr. Okun

Post of the Week: Using Microelectrode Recording for DBS

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Dear forum members,


Neurologists and physiologists may use a tool in the operating room to find the exact location to place a DBS lead for Parkinson's disease. Millimeters may make a difference in outcome. This group from the Netherlands advocates using multiple passes with the microelectrode to choose the best target. They point out that in many cases they chose a target that was not their predicted target. More studies will be needed to clarify outcomes but patients should take home the importance of having an experienced microelectrode recording person if they have DBS and this procedure is utilized. Here is the abstract.



Acta Neurochir (Wien). 2010 Oct 15. [Epub ahead of print]

Long-term experience with intraoperative microrecording during DBS neurosurgery in STN and GPi.

Bour LJ, Contarino MF, Foncke EM, de Bie RM, van den Munckhof P, Speelman JD, Schuurman PR.


Department of Neurology/Clinical Neurophysiology, University of Amsterdam, Amsterdam, The Netherlands, bour@amc.nl.


BACKGROUND: Intraoperative microelectrode recording (MER) for targeting during deep brain stimulation (DBS) procedures has been evaluated over a period of 4 years, in 57 consecutive patients with Parkinson's disease, who received DBS in the subthalamic nucleus (STN-DBS), and 28 consecutive patients with either dystonia (23) or Parkinson's disease (five), in whom the internal segment of the globus pallidus (GPi-DBS) was targeted.


METHODS: The procedure for DBS was a one-stage bilateral stereotactic approach using a combined electrode for both MER and macrostimulation. Up to five micro/macro-electrodes were used in an array with a central, lateral, medial, anterior, and posterior position. Final target location was based on intraoperative test stimulation.


FINDINGS: For the STN, the central trajectory was chosen for implantation in 50% of the cases and for the globus pallidus internus (GPi) in 57% of the cases. Furthermore, in 64% of the cases, the channel selected for the permanent electrode corresponded with the trajectory having the longest segment of STN MER activity. For the GPi, this was the case in 61%. The mean and standard deviation of the deepest contact point with respect to the magnetic resonance imaging (MRI)-based target for the STN was 2.1 ± 1.5 mm and for the GPi was -0.5 ± 1.2 mm.


CONCLUSIONS: MER facilitates the selection of the final electrode location in STN-DBS and GPi-DBS, and based on the observed MER activity, a pre-selection could be made as to which channel would be the best candidate for macro-test stimulation and at which depth should be stimulated. The choice of the final location is based on intraoperative test stimulation, and it is demonstrated that regularly it is not the central channel that is chosen for implantation. On average, the target as defined by MER activity intensity was in accordance with the MRI-based targets both for the STN and GPi. However, the position of the best MER activity did not necessarily correlate with the locus that produced the most beneficial clinical response on macroelectrode testing intraoperatively.


PMID: 20949292 [PubMed - as supplied by publisher]

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